启明星 | 全球AI制药领军企业英矽智能成功登陆港交所 | Bilingual

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北京时间2025年12月30日，**启明创投投资企业、全球领先的AI制药公司英矽智能（Insilico Medicine）成功登陆香港交易所，成为2025年港股市场最大Biotech IPO。**英矽智能（03696.HK）发行价24.05港元/股，开盘价35.00港元/股，市值195.1亿港元。

2019年，启明创投领投了英矽智能的B轮融资，并在C轮和D轮继续支持公司发展。IPO前启明创投持有英矽智能约7%的股份，是公司最重要的机构投资方之一。

英矽智能成立于2014年，商业模式以Pharma.AI平台为基础，聚焦通过人工智能进行内部药物研发，并逐步将Pharma.AI的应用范围扩展至先进材料、农业、营养产品、兽医药物等多个行业，现已高效搭建了涵盖超过30个创新项目的管线组合，在需求广泛的肿瘤、免疫、纤维化、代谢等领域都有涉及，并手握全球进展最快的AI药物。

截至目前，全球收入最高的20家药企中13家都和英矽智能达成了软件平台合作； 此外，英矽智能与Exelixis、美纳里尼等全球制药企业达成了3项管线授权合作，为公司带来20亿美元的潜在收入；同时，包括赛诺菲、礼来、复星医药等在内的多家全球知名制药企业与英矽智能达成了药物研发合作。

英矽智能创始人兼首席执行官、首席商务官Alex Zhavoronkov博士表示： “英矽智能致力于延长人类健康寿命，此次上市将为推进这项使命提供更多资源。过去几年，我们用验证了人工智能赋能的项目从靶点发现到分子生成、再到临床前和临床阶段的端到端能力。未来，我们将继续加大在人工智能平台和创新管线上的投入，加速更多具有全球差异化优势的创新项目进入临床，为全球患者带来真正可及、可负担、且具有突破性的治疗方案。”

启明创投合伙人、医疗创新行业共同负责人陈侃博士表示：“投资英矽智能，我们是基于‘AI将深刻改变药物研发的路径与效率’这样一个简单的信念。2019年我们决定投资英矽智能，正是看中了团队在生成式AI尚未普及时的前沿探索。如今，通过临床前验证和管线授权，英矽智能在AI制药领域的价值正逐步落地。未来，我们期待AI不仅赋能早期研发，更能切实加速临床阶段进程，让新药更早惠及患者。”

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Qiming Venture Partners' Insilico Medicine Successfully Lists on Hong Kong Stock Exchange

Insilico Medicine (03696.HK), a global leader in AI-driven drug discovery and a portfolio company of Qiming Venture Partners, today successfully listed on the Hong Kong Stock Exchange (HKEX). The listing marks the largest biotech IPO on the Hong Kong stock market in 2025. With an issue price of HK$ 24.05 per share, Insilico Medicine opened at HK$35.00 per share, representing a market capitalization of approximately HK$ 19.51 billion.

Qiming Venture Partners is one of Insilico Medicine's most important institutional investors. Qiming Venture Partners led the Company's Series B financing round in 2019 and continued its support in subsequent Series C and D rounds, with an about 7 percent stake in Insilico Medicine before its IPO.

Founded in 2014, Insilico Medicine employs a business model based on the Pharma.AI platform, focuses on internal drug research and development through artificial intelligence. It has gradually expanded the application of Pharma.AI to more industries such as advanced materials, agriculture, nutritional products, and veterinary drugs. It has now efficiently built a pipeline portfolio covering over 30 innovative projects in a wide range of fields with extensive demands, such as oncology, immunology, fibrosis, and metabolism, and owns the world's most advanced first-in-class AI-based drugs.

To date, 13 of the world's top 20 pharmaceutical companies by revenue have entered into software platform collaborations with Insilico Medicine. Insilico Medicine has also reached licensing agreements on three pipelines with global drugmakers such as Exelixis and Menarini, bringing a potential revenue of USD2 billion for the company. The Company has also established drug R&D partnerships with other internationally renowned pharmaceutical firms including Sanofi, Lilly, and Shanghai Fosun Pharmaceutical (Group) Co., Ltd.

"Insilico is dedicated to extending human productive longevity and this listing provides us with more resources to advance our mission. Over the past few years, we set very clear industry benchmarks demonstrating that AI can help make drug discovery faster, cheaper, and deliver higher success rates in preclinical and early clinical development. We have validated the end-to-end capabilities of AI-empowered programs from novel target discovery to molecular generation, and then to preclinical and clinical stages. Going forward, we will continue to increase investment in our AI platform and innovative pipeline, accelerate the advancement of differentiated innovative programs into clinic, and bring truly accessible, affordable, and breakthrough treatment solutions to patients worldwide." said Alex Zhavoronkov, PhD, Founder and CEO, Chief Business Officer of Insilico Medicine.

"We invest in Insilico Medicine based on a simple belief that 'AI will profoundly change the pathway and efficiency of drug development.' We decided to invest in Insilico Medicine in 2019 because of its research in frontier areas when generative AI was not yet popularized. Now the value of Insilico Medicine in the field of AI pharmaceuticals is gradually being realized through preclinical validation and pipeline licensing. We expect AI to not only empower early-stage research and development but also effectively accelerate the clinical stage process in the future to enable new drugs to benefit patients earlier," Dr. Chen Kan, Partner and Healthcare Co-Lead at Qiming Venture Partners, said.

往 期 回 顾

启明观点 | 启明创投陈侃：AI对生物医药行业的变革已经显现 对话 | 启明创投胡旭波对话英矽智能任峰：AI如何驱动下一代药物研发 启明荣誉 | 5位启明创投投资人荣登2025年福布斯中国创投人100榜单

启明创投成立于2006年。目前，启明创投旗下管理11只美元基金，7只人民币基金，已募管理资产总额达到95亿美元。自成立至今，专注于投资科技(Technology)、医疗创新(Healthcare)等行业早期和成长期的优秀企业。

截至目前，启明创投已投资超过580家高速成长的创新企业，其中有超过210家分别在美国纽交所、纳斯达克，香港交易所，上交所及深交所等交易所上市，或通过并购等方式退出，有80多家企业成为行业公认的独角兽或超级独角兽企业。

启明创投投资企业中，很多已经成长为各自领域中最具影响力的公司，包括小米集团（01810.HK）、美团（03690.HK）、哔哩哔哩（NASDAQ:BILI, 09626.HK）、知乎（NYSE:ZH, 02390.HK）、石头科技（688169.SH）、禾赛科技（NASDAQ:HSAI,02525.HK）、优必选（09880.HK）、文远知行（NASDAQ:WRD, 00800.HK）、海博思创（688411.SH）、影石创新（688775.SH）、云知声（09678.HK）、甘李药业（603087.SH）、泰格医药（300347.SZ, 03347.HK）、再鼎医药（NASDAQ:ZLAB, 09688.HK）、康希诺生物（688185.SH, 06185.HK）、Schrödinger（NASDAQ:SDGR）、惠泰医疗（688617.SH）、三友医疗（688085.SH）、艾德生物（300685.SZ）、神州细胞（688520.SH）、英矽智能（03696.HK）、浩博生物、圆心科技、宜联生物、礼新医药、智谱、阶跃星辰、壁仞科技等。